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Pharma Process Solutions
to become more MORE EFFECTIVE
#We know your industry
✓ CMO/CDMO
✓ Vaccines & Heparins
✓ Biologics
✓ Generic & Biosimilars

✓ Cell & Gene
✓ Veterinary
✓ Research & Development
✓ Eye Drop & Nasal

PROCESS SOLUTIONS BY GRONINGER. CUSTOMER-ORIENTED AND FLEXIBLE.

We master our customers’ tasks through creative ideas and convincing concepts and are already developing new solutions for the requirements of the future. We demonstrate our claim to technological leadership for aseptic filling machines and pharmaceutical processes through constant improvement and passion for exceptional performance. 

Highlights

Find out how groninger process solutions can simplify your production, make processes safer and at the same time significantly increase machine availability.

Minimum possible product loss

The groninger SMARTFILL technology reduces product loss by up to 99% during the start-up process, during production mode and at the end of the batch.

Shortest changeover times

The QUICKCONNECT technology enables simple, guided and tool-free changeover with a time saving of up to 60%.

Correct component infeed processes

groninger‘s SAFETRANSFER philosophy
offers the safest processes for your requirements when feeding pre-sterilized components into the aseptic zone.

Intelligent sorting unit

The innovative groninger sorting unit reduces the number of format parts and simplifies line setup.

Best availability of format parts

The groninger FASTLANE offers time savings of up to 50% when providing new or additional format sets.

Three formats on one platform

The groninger COMBIFILL philosophy enables the processing of nested syringes, vials and cartridges on one machine platform by changing the format parts.

Additional Features

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Optimal machine operation

Depending on the requirements, groninger machine concepts are designed for one-sided machine operation, enabling an operating concept that is up to 30% more optimized, while significantly minimizing risk.

Maximum availability

A high level of automation of all aseptically critical processes ensure the highest level of OEE.

Lowest number of format parts

We have reduced the number of formats compared to conventional filling machines by up to 40% by continuous optimization of functions and processes.

Highest degree of automation in a small space

Automation and good manufacturing practice (GMP) also play an important role in research and development. groninger offers automated solutions for smaller spaces or laboratories.

Scalable output

The scalable line designs enable output to be adjusted to the product requirements.

End-to-end process solutions

groninger offers end-to-end and scalable process solutions from R&D to clinical studies to various performance classes in the production environment.

Contact us!

Are you interested
– we will help you to become more effective!

Contact us – on the phone, by email or directly at our office.

Contact for USA and Canada
Email  info@groningerusa.com
Phone +1 704 295-9000

Contact outside USA and Canada
Email office@groninger.de
Phone +49 7951 4950


    *Required Field

    We know your industry.

    The current changes in the pharmaceutical industry demand market leaders like groninger to have a very high level of know-how and expertise in all aspects of pharmaceutical processes, products and system designs. Groninger is the right partner at your side because we know what is important in your industry. We know pharmaceuticals.

    At groninger, we follow the current trends in the pharmaceutical markets closely and have developed a wide range of accessories for all aspects of aseptic filling. Therefore, we offer you comprehensive process solutions – perfectly tailored to your requirements. See for yourself and find out about our know-how, impressive features, perfectly coordinated processes and unique solutions.

    Contract Manufacturing Organization

    Maximum flexibility and fastest possible response times to changing customer and market needs are the essential requirements for CMOs. groninger offers optimal state-of-the-art solutions – fastest delivery times for format sets, shortest changeover times and maximum utilization (OEE).

    NEST PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times​
    • SMARTFILL – Minimum possible product loss
    • COMBIFILL – 3 formats on one platform
    • FASTLANE – Best availability of format parts

    VIAL PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times​
    • SMARTFILL – Minimum possible product loss
    • FASTLANE – Best availability of format parts
    • Lowest number of formats

    Vaccines & Heparins

    A growing population, demographic change, but also the risk of global infectious diseases increase the need for vaccinations and heparin treatments worldwide. groninger provides processing of large quantities in the shortest possible time with maximum and effective output without compromising.

    NEST PROCESSING HIGHLIGHTS

    • SMARTTRACK – Intelligent sorting unit
    • Maximum availability
    • Consistent process solutions
    • Scalable output

    VIAL PROCESSING HIGHLIGHTS

    • Optimal machine operation
    • Consistent process solutions
    • Maximum availability
    • Scalable output

    Generic drugs and biosimilars

    Efficiency and quality – groninger guarantees these success factors. When processing generics and biosilimars, a quick format change and high system availability are essential. We deliver the right technology, flexibility and reliability to ensure production remains cost-effective.

    NEST PROCESSING HIGHLIGHTS

    • COMBIFILL – 3 formats on one platform​
    • SMARTTRACK – Intelligent sorting unit
    • Consistent process solutions
    • Maximum availability

    VIAL PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times​
    • SMARTTRACK – Intelligent sorting unit
    • Maximum availability
    • Consistent process solutions

    Biologics

    High-quality and, therefore, expensive products – groninger has the right answers to these challenges. Our lines ensure minimal product loss during production, shortest set-up times and, as a result, maximum flexibility with proven processes and technology.

    NEST PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times​
    • SMARTFILL – Minimum possible product loss
    • COMBIFILL – 3 formats on one platform
    • Lowest number of formats

    VIAL PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times​
    • SMARTFILL – Minimum possible product loss
    • Lowest number of formats
    • High degree of automation in a small space

    Cell and Gene Therapies

    Our portfolio is characterized by the highest level of employee protection, minimal product loss and the processing of sterile glass and polymer vials in the most compact space.

    VIAL PROCESSING HIGHLIGHTS

    • QUICKCONNECT – Shortest changeover times
    • SMARTFILL – Minimum possible product loss
    • Lowest number of formats
    • High degree of automation in a small space

    Veterinary

    Rising pet ownership increases the need for veterinary products worldwide. For products with a high filling volume, groninger guarantees maximum and effective output without compromise.

    VIAL PROCESSING HIGHLIGHTS

    • FASTLANE – Best availability of format parts
    • SMARTTRACK – Intelligent sorting unit
    • Lowest number of formats
    • Maximum availability

    Research and Development

    When filling drug development or clinical studies, it is necessary to use proven and scalable line processes and functions. groninger offers a system concept on a laboratory scale that meets these requirements, and reliably supports a quick and safe transition from laboratory scale to the production environment.

    NEST PROCESSING HIGHLIGHTS

    • COMBIFILL – 3 formats on one platform
    • FASTLANE – Best availability of format parts
    • Consistent process solutions
    • High degree of automation in a small space

    Manufacture of eye drops & Nasal spray

    Demographic change and increasing population numbers increase the need for eye and nasal treatments worldwide. The processing of large quantities requires maximum and effective output without compromise – this is exactly what groninger offers!

    VIAL PROCESSING HIGHLIGHTS

    • Lowest number of formats
    • Maximum availability
    • Consistent process solutions
    • Scalable output

    WE KNOW pharma.

    Since the founding of our company in 1980, our contributions ensure that people are supplied with high quality pharmaceutical products. Groninger machines and systems are used worldwide.

    Our worldwide network of sales partners spans across all continents in the world. Our groninger systems are produced at our locations in Germany and in the US – quality „made in Germany“ and „made in USA“. In order to always be up to date, we are constantly researching the latest trends, actively seeking dialog and we are already working on the ideas of tomorrow to continue to set standards in the international pharmaceutical markets.

    Our experience and range of services does not only extend to filling and closing systems, we provide you with comprehensive consulting–from the manufacture of Ready-To-Use (RTU) packaging materials, the aseptic and aseptically toxic filling of drugs to the necessary post-processing. Thanks to our 40 years of process and system expertise, we are able offer you a complete solution for your application.

    YOUR COMPETITIVE ADVANTAGE: OUR SERVICE.

    Mechanical engineering is subject to constant change. Many factors change. Service is a very important aspect of this global development. We are quickly at your site, have very good and experienced employees, an extensive supply network and a variety of clearly defined services. Our customers greatly appreciate that.

    We are not only renowned for excellent mechanical engineering and complete process solutions, but also for comprehensive services. The quick and very personal customer support on site is a key success factor. In addition to the well-known services, we also offer digital services to meet today’s and future requirements – digital mock-ups and design reviews, digital FATs, as well as remote maintenance and remote training using a digital twin are just a few examples. Higher productivity, shorter changeover times and optimal maintenance are key terms. The permanent availability of the system is our customers’ requirement, which we, as the manufacturer, are happy to face every day. Therefore, we provide support throughout the entire life cycle of your system. 

    Our Process know-how

    The aseptic infeed of RTU packaging material into the aseptic processing zone is an extremely critical process. There are a number of proven process solutions that can be used depending on customer and product requirements. groninger offers a solution for every type of requirement for your production. With our experience and technologies, you will receive the best advice from the concept phase throughout the entire product life cycle of your system.

    Infeeding and zone concepts

    Traditional bulk processing is one of groninger’s key areas. With our comprehensive consulting know-how and experience, we are able to advise and support you on all matters relating to the field of aseptic vial filling. We also offer extensive knowledge in the field of aseptically toxic system concepts and various zone concepts based on a large number of implemented projects. This is how we are able to offer you the best processes for your needs.

    ASSEMBLY & POST-PROCESSING

    The groninger downstream equipment range ensures safe and high-quality postprocessing of pharmaceutical primary packaging.

    We offer a complete range of machines specifically for syringes, vials and cartridges with the associated components such as plunger rods, labels, backstops and safety devices. Depending on the requirements, our machines can be configured for an output of up to 600 units/minute. groninger also has extensive experience in integrating downstream equipment. This allows us to easily integrate our machines into line designs, or set them up as separate systems.

    Additional equipment features by groninger

    Due to the change in the pharmaceutical industry, the demands on suppliers of aseptic filling technology based on a high level of process and industry know-how are also increasing. This exact know-how is what distinguishes groninger! With an extensive, proven system portfolio and a high level of innovation for new technologies and processes, we always provide the highest level of process reliability through the greatest possible risk minimization. 

     

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    Broad portfolio from R&D requirements to high speed production lines

    Our groninger machine designs are designed for operation from one side depending on the requirements and thus optimize the operating concept by up to 30%.

    Annex 1 compliance processes

    Today´s groninger machine portfolio meets already the requirements of the revised Annex 1.

    TurnKey project management

    groninger coordinates your projects including isolator and freeze drying technologies.

    Comprehensive risk based analysis

    Our designs and processes are based on risk based approaches.

    Universal single-use filling equipment

    The comprehense groninger single-use portfolio is applicable for all aseptic filling lines.

    Successful Partnership

    Many of our customers are world market leaders in their industry. But we also work with the same passion for all those who are not or would like to become.

    Syed Husain,
    Senior Vice President and Head of CDMO Business Unit at Emergent BioSolutions
    Read more "The FlexPro50 gives us the flexibility we need to serve our customers."
    Dermot O‘Riordan,
    Business Development Manager
    Read more "With the FlexPro50, we accommodate all our requirements as a CMO for potent products."
    Sjaak Stevense,
    Director Commercial Productions
    Read more „We found Groninger the “best-in-class” partner and supplier for our new aseptic Fill & Finish line to meet our high expectations and our GMP quality requirements.“
    Medhat Gorgy,
    President and CEO
    Read more "The groninger FlexFiller line will increase both our capacity and flexibility as a CMO."
    Chris Blanton,
    Vice President and General Manager
    Read more "The groninger downstream syringe assembly equipment enables us to offer the greatest flexibility for our clients."